Differently from the national result, the election was won by the centre-right coalition of the House of Freedoms.

Forza Italia was the largest party in the election with 28%, ahead of the Democrats of the Left (12%) and Lega Nord (11%).

Forza Italia had lost 5 points at regional level during the 2004 European election, while the Province of Milan shifted to the left in the same occasion.

On the other side, in 2005 Romano Prodi had launched his new larger coalition, The Union, merging in a single alliance quite all oppositions to Berlusconi's majority: The Olive Tree, the Communist Refoundation Party and Antonio Di Pietro's Italy of Values, which in Lombardy were joined by the Lombard Autonomy League.

Respecting this condition, seats are divided between coalitions, and subsequently to party lists, using the largest remainder method with a Hare quota.