Vettor Pisani was the lead ship of her class of four submarines built for the Regia Marina (Royal Italian Navy) during the late 1920s.

Vettor Pisani briefly had Junio Valerio Borghese as commander during the Second World War.

Designed in parallel with the Mameli-class submarines, the Pisani class was larger accommodate more fuel and give them more range.

[1] For surface running, the boats were powered by two 1,500-brake-horsepower (1,119 kW) diesel engines, each driving one propeller shaft.

[3] During the Spanish Civil War, she unsuccessfully attacked a ship during a patrol she conducted off Barcelona, Spain, from 7 to 20 August 1937.