Rail services from all 4 major metropolitan cities of India namely Mumbai to Kolkata and Delhi to Chennai pass through Itarsi.

Monsoon begins from the month of July and lasts up-to September with maximum rainfall of the District being 326.4 mm.

In the British Colonial Era,[5] Itarsi gained prominence as a strategic railway junction connecting major cities in Central India.

Evolving into a significant transportation hub, Itarsi became a key center for the movement of goods and passengers, contributing to its economic growth.

Its diverse cultural and demographic mix reflects Itarsi's status as a vibrant urban center.

The total population in Itarsi sub district is 240,719 as per the survey of census during 2011 by Indian Government.

Itarsi is connected via broad gauge lines to Bhopal and Delhi to the north, Bhusawal and Mumbai to the west, the railway junctions of Nagpur to the south and Jabalpur to the east.

Rail services from Mumbai to Guwahati and Delhi to Chennai pass through Itarsi.

National Highway (NH-69) connects Itarsi to major cities Bhopal and Nagpur.

[8] As one of the oldest Diesel Loco Sheds, it was opened in the year 1964 with a total number of 40 locomotives.

[12] In 2014, amidst reports of contact dermatitis caused by diesel handling in other Indian Railway sheds,[13] around 100 mechanics from Itarsi shed also reported persistent skin afflictions.