Ithaca is a village in Darke County, Ohio, United States.

John Colville platted Ithaca in 1832 and gave it the name of "Twinsborough."

Its location on an established highway and along the Ohio Electric Railway caused the community to grow rapidly.

[6] According to the United States Census Bureau, the village has a total area of 0.03 square miles (0.08 km2), all land.

There were 52 housing units at an average density of 1,733.3 per square mile (669.2/km2).

16.7% of all households were made up of individuals, and 8.3% had someone living alone who was 65 years of age or older.