They were promoted to the Campeonato Paulista, the top-flight professional football league in São Paulo in 1989 after clinching the Série A2 championship.

In 2003, Ituano became the champion of the Campeonato Brasileiro Série C after surpassing teams like Santo Andre who won the Copa Do Brasil one year later.

In 2007, Ituano were relegated back to the Brasileiro Serie C after finishing in last place and one year later were not playing in the Brazilian top 4 divisions.

In 2014, Ituano became one of the few teams outside of the São Paulo metroplex area to win the Campeonato Paulista twice beating Santos in the final.

Juninho joined in a player-president capacity helping the team avoid relegation on the final day of the 2010 season with the decisive goal in a 3–2 victory.

[2] In 2014, Ituano won the Campeonato Paulista, defeating the storied Santos Futebol Clube on penalty kicks.