[11] He received interest from a number of clubs, including Anderlecht, PSV, Ajax, Hertha BSC and Hamburger SV.

[11] Sochaux's coach Alain Perrin personally arrived to Split with a private jet to convince Perišić to sign, waiting two days for his signature.

In the 2010–11 season, he was the top scorer of the Belgian Jupiler Pro League after scoring 22 goals for Club Brugge, also being named Player of the Year in Belgium.

[25] He made his debut for the club in their 3–1 home victory over Hamburger SV on 5 August, substituting on for Chris Löwe in the 75th minute.

[26] During a Champions League match on 13 September 2011, he scored a late equaliser with a volley from 20 yards against Arsenal after entering as a substitute in the 69th minute.

[28] On 21 April 2012, he scored the important 1–0 goal against Borussia Mönchengladbach and opened the door to the eighth national championship for Dortmund.

[39] Perišić finished the season with ten league goals, second-best on the team behind fellow countryman Ivica Olić.

[citation needed] On 30 August 2015, Perišić signed with Italian club Inter Milan on a five-year contract[40] for a transfer fee of €16 million.

[41] He was presented on 10 September alongside Adem Ljajić, where he was assigned squad number 44, stating, "Inter were too big an opportunity to turn down.

"[42] Perišić made his competitive debut for the club three days after signing, starting and playing 85 minutes in a 1–0 win against cross-city rivals Milan in the Derby della Madonnina.

[43] He opened his scoring account on 4 October in his fifth league appearance in the 1–1 away draw against Sampdoria, profiting from Mauro Icardi's assist,[44] which was followed by another goal against Palermo two weeks later.

[55] On 20 November, in the Derby against rivals Milan, he first provided the Antonio Candreva's long-range strike before scoring himself a last minute equaliser, as Inter took one point in the last moments.

[60] He returned from suspension on 19 February in the 1–0 win at Bologna,[61] and scored his second brace on 5 March in a 5–1 thrashing of Cagliari at Stadio Sant'Elia.

Teammate Mauro Icardi's agent Wanda Nara spoke out about Perišić's reasons for the departure, speculating that they might be of personal nature.

[75][76][77] Perišić featured in 34 matches in Serie A, only behind Samir Handanović and Matteo Politano, scoring 8 goals; hence being the second top scorer for Inter after Icardi.

[80] On 4 February 2020, during training ahead of a DFB-Pokal match against 1899 Hoffenheim, Perišić suffered a right ankle fracture following a tackle from teammate Álvaro Odriozola.

[84] On 4 July, he provided Robert Lewandowski with an assist in the DFB-Pokal final as Bayern defeated Bayer Leverkusen 4–2 and secured the domestic double.

[88] On 23 August, he became the eleventh Croatian to win the Champions League in history, as Bayern defeated Paris Saint-Germain 1–0 in the final.

[92] During the spring part of the season, Perišić was praised by Conte for successfully adapting to his system, moving from the position of a winger to that of a wing-back.

[93][94] On 2 May 2021, four matchdays before the end of the season, Sassuolo drew 1–1 with Atalanta at home, meaning that Inter mathematically secured the Serie A title.

[105] Perišić made his Premier League debut on 6 August 2022, coming on as a second-half substitute for Ryan Sessegnon in a 4–1 home victory over Southampton.

[106] On 20 September 2023, the club confirmed that Perišić had sustained a complex anterior cruciate ligament injury in his right knee in non-contact training and that he would undergo surgery.

[114] During the 2014 World Cup qualification, Perišić appeared in 12 matches for Croatia and scored his first international goal in a 1–1 draw with Belgium.

[118] Perišić was in Croatia's starting team for the opening match of the 2014 World Cup, a controversial 3–1 defeat to tournament hosts Brazil at the Arena Corinthians, São Paulo.

[124] Five days later, he scored the winning goal against Spain, which secured qualification to the knockout stage as group winners for Croatia.

[125] Perišić appeared regularly in Croatia's successful 2018 FIFA World Cup qualifying campaign, as they finished runner-up in Group I which sent them to second round.

[127] Croatia booked their spot to the World Cup final stages in Russia on 12 November by playing a goalless draw in the returning leg.

[139][140] On 1 June 2021, Perišić made this 100th appearance for the national team in a friendly 1–1 draw with Armenia in which he scored Croatia's goal.

[141] He was selected in Croatia's final squad for UEFA Euro 2020, where he was the team's most efficient performer, scoring twice (in the 1–1 draw with the Czech Republic and the 3–1 victory over Scotland) and assisting once (in the latter match).

[145][146][10] Perišić took part at the 2017 FIVB Beach Volleyball World Tour for the Poreč Major tournament, a professional competition, partnering Nikša Dellorco.