Bundesliga for FC Ingolstadt on 8 March 2009, when he came on as a substitute in the 72nd minute in a game against 1860 Munich and scored his first goal.

[5] In the final of the Belgian Cup in 2016, Santini scored a goal in the 88th minute of the match to secure a dramatic 2–1 win over Club Brugge.

[13] On 29 July 2019, Santini joined Chinese Super League club Jiangsu Suning, becoming their fifth and final allotted foreign born player for the season.

[14][15] On 24 October 2020, Santini's ninth minute strike against Chongqing Lifan secured Jiangsu Suning a place in the semi-finals of the 2020 Chinese Super League play-offs against 2018 title winners Shanghai SIPG.

[16] Santini was a substitute in the second-leg of the CSL final against Guangzhou Evergrande on 12 November, coming on in the 80th minute for goalscorer Éder.

[22] Santini made his debut for Croatia in a May 2017 friendly match against Mexico and earned a total of five caps, scoring no goals.