1994 – graduated from the National Pedagogical Drahomanov University, a speciality – defectology and speech therapy.

1991–1993 – Speech therapist at the Children's Territorial Medical Association of Starokyivsky District; 1994–1999 – Project Manager, Head of the Department of International Relations, NGO 'Ukrainian Independent Center for Political Studies'; 1999–2002 – Project Manager at 'Kyiv Center of the East-West Institute'; 2001–2002 – Acting Director of the 'Kyiv Center of the East-West Institute'; 2002–2007 – Correspondent in the Ukrainian BBC Radio Service (BBC) in US (Washington) and in the Caucasus (Tbilisi); 2007–2009 – Deputy Director for Programs of the International Charitable Organization 'Fund for Support of International Cooperation of Ukraine' ('Open Ukraine Foundation'); 2009–2011 – Director of the International Charitable Organization "Fund for Support of International Cooperation of Ukraine" ("Open Ukraine Foundation"); Since 2011 – Director of charitable organization 'Yalta European Strategy'; In 1994–99 Ivanna Klympush worked for the Ukrainian Independent Center of Political Research, while attending the Institute of International Relations in University of Kyiv which she graduated in 1998. board member of the Public Organization 'Ukrainian Media Center' ('Ukrainian Crisis Media Center'); Alumni of 'Aspen-Ukraine' Association; Member of supervisory boards of the NGO 'Institute for Economic Research and Policy Consulting' and NGO 'Ukrainian Institute of Public Policy'.

During the elections to the Verkhovna Rada of the VIII convocation (2014) she passed to the Parliament from the party Petro Poroshenko Bloc 'The Solidarity' under the number 61.

In the July 2019 Ukrainian parliamentary election Klympush-Tsintsadze was placed tenth on the party list of European Solidarity.

24 November 2016 Ivanna Klympush-Tsintsadze and Johannes Hahn (European Commissioner for Neighbourhood and Enlargement Negotiations) signed the agreement on financing the EUACI.