[1] At the 2006 Australian Open, for the first time, she reached the third round of a Grand Slam championship by beating fifth seed Mary Pierce.

Despite losing her singles rubber to Nuria Llagostera Vives, the Czech team advanced to the semifinals after winning the tie 4–1.

Seeded 6th at the first edition of the Monterrey Open, she beat fellow Czech Barbora Záhlavová-Strýcová in the quarterfinals before losing in the semifinals to unseeded Li Na.

Along with Barbora Záhlavová-Strýcová, she grabbed the titles in Paris as their opponents Cara Black and Liezel Huber withdrew and Monterrey defeating Anna-Lena Grönefeld and Vania King.

Partnering with Anabel Medina Garrigues, Benešová won Fes, making her winning both singles and doubles in the tournament.

[5][6] Benešová once again reached the fourth round of the Australian Open, being defeated by eventual champion Victoria Azarenka in straight sets.

At the French Open, she played the mixed doubles with her then husband Jürgen, they lost in the first round against top seeded Alexander Peya and Abigail Spears.

[7][8][9] Only main-draw results in WTA Tour, Grand Slam tournaments, Fed Cup and Olympic Games are included in win–loss records.