She was elected to the European Parliament in 2014 as the sole representative for the Union of Greens and Farmers.

[5][6] On 16 October 2014 it was reported that Grigule was defecting to the European People's Party, leading to the crisis in the EFDD group as it was temporarily one country short of the required seven member states.

[7][8] Nigel Farage, EFDD co-president and head of UKIP (whose members made up more than half the group), claimed that Grigule was pressured to stand down if she wanted to lead a parliamentary delegation to Kazakhstan.

[10] In 2016 Grigule voted against a European Parliament resolution to condemn Russia's use of propaganda.

[11][12] Initially she refused to publicly explain her voting record,[13] but after meeting with the Latvian Farmers' Union chairman Valdis Veinbergs Grigule claimed that she had voted against the resolution because she believed it popularized Islam.