It is located approximately 36 km (22 mi) from Xalapa Enríquez; Federal Highway 123 runs through it.

Coffee is the chief product of Ixhuacán de los Reyes.

In August, 1519 Hernán Cortés passed through Ixhuacán on his way to Tenochtitlan.

Both Cortes and his chronicler Francisco Lopez de Gomara described the town as having a fort.

Ixhuacán de los Reyes has a subtropical highland climate (Cfb) with cool to mild weather year-round.