First mentioned in a church document from 1419, Izbica became a town in 1750, granted location privileges by Augustus III of Poland including the right of a Jewish settlement.

Previously, the unconcluded town rights were issued in 1540 to Hetman Jan Tarnowski, who gave them back to the crown.

In 1744 the Jews of Tarnogóra were brought to Izbica by Antoni Granowski who secured the town privileges for them independently of the preexisting old settlement.

[2] After the January Uprising of 1863 against the Russian Empire, in which many of the local inhabitants took part, the town was stripped of its city rights in 1869 for punishment, and attached to the nearby commune of Tarnogóra.

In the spring of 1941 in preparation for the attack on the Soviet lines in eastern Poland the German military storage facilities were set up in Izbica, and kept under heavy guard.

[3] The first mass deportation of ghetto inmates to the Bełżec extermination camp took place in mid-March 1942 conducted by the Reserve Police Battalion 101 with the aid of Ukrainian Trawnikis.

[4] During Operation Reinhard the ghetto served as a transfer point to the extermination camps in Bełżec and Sobibór for foreign Jews deported from Germany, Austria, Czechoslovakia and western Poland (Reichsgau Wartheland).