He made his Premier League debut for Arsenal against Fulham in the 2001–02 season, replacing Thierry Henry in a 4–1 victory.

[10] He also scored twice against Wolverhampton Wanderers in the following round of the League Cup,[11] his second winning goal for the month for December.

On his return, he made six substitute appearances for the first team, including the FA Cup semi-final against Blackburn Rovers.

[18] In the summer of 2005, Aliadière was sent on loan to Scottish club Celtic for the entire 2005–06 season in order to play regular first team football.

[19] In the end, his time at Celtic was forgettable; he made just two substitute appearances for the club, one in each leg of their loss to Artmedia Bratislava in the Champions League.

[24] Aliadière returned to Arsenal during the 2006–07 season but was again mainly used in the League Cup, scoring both goals in their 2–0 win over West Brom on 24 October 2006.

[25] His first Premier League appearance of the season came on 16 December 2006, a 2–2 draw against Portsmouth, with Aliadière playing for 55 minutes before being replaced by Emmanuel Adebayor.

The move, however, failed to happen after Robin van Persie broke his foot, and he was told to stay at Arsenal for the time being.

[29] He scored his first goal in a Premier League match against Manchester United at Old Trafford in October 2007, with a header to draw level at 1–1, before Middlesbrough went on to lose the game 4–1.

It was the cause of controversy after Middlesbrough's consequent appeal was deemed as "frivolous" by The Football Association (FA) and extended by one more game, with the club's chairman and chief executive, and Tottenham manager Harry Redknapp, deeming this unfair and criticising The FA, contrasting it with a recent appeal by Chelsea's Michael Essien.

His first Premier League goal of the season came in a 1–0 win against Wigan Athletic at the JJB Stadium on 4 October 2008, scoring in the 89th minute of the match.

[36] At the end of the season, Middlesbrough finished equal bottom of the Premier League with West Brom, on 32 points, and as a result were relegated to the Championship.

[37] The 2010–11 pre-season found Aliadière training with West Ham with a view to a permanent move to the London club.

[42] On 5 July 2011, Aliadière signed for Ligue 1 club Lorient on a free transfer, with an option for a three-year deal.

[54] In Lorient's Brittany derby with Rennes on 2 February 2013, Aliadière scored the team's second goal in a 2–2 draw.

"[56] Aliadière converted a penalty to open the scoring in a 2–1 defeat of Evian on 16 February, keeping Lorient within reach of securing European football.

[57] Aliadière expressed his pleasure at playing for manager Christian Gourcuff, stating that "his vision of football ... means very good organization defensively".