[5] In December 2020, Bouzas Maneiro reached her first professional singles final at the $15k Torneo Internacional de Tenis Ciudad Raqueta in Madrid, but was defeated by Conny Perrin.

[18] She made her WTA 1000 main-draw debut, after qualifying for the Madrid Open where she defeated compatriot Paula Badosa in the first round for her first win at this level.

[19][20] At Wimbledon, Bouzas Maneiro reached the third round of a major for the first time in her career, after upsetting defending champion Markéta Vondroušová in straight sets,[21][22] her first top 10 win, and defeating compatriot Cristina Bucșa.

[24] She exited the tournament after retiring due to a back injury while trailing in her round three match against eventual champion Barbora Krejčíková.

[25] She also made her debut at the Cincinnati Open when she defeated fellow lucky loser Lucia Bronzetti [26] before losing to Elina Svitolina.

[27] Bouzas Maneiro reached another major third round at the US Open with wins over Petra Martić[28] and 31st seed Katie Boulter.

Maristany made her debut representing Spain in multi-sports event at the 2022 Mediterranean Games where she won the singles bronze and the women's doubles gold medal.