He began to study at the metropolitan seminary of the Archdiocese of Kraków in 1975 after completing his high school exams.

He was ordained on 17 May 1981 in Wawel Cathedral by Franciszek Macharski.

[3] Between 1994 and 1998, Guzdek served as prefect for the seminary of the Archdiocese of Kraków.

He received a doctorate in theology in April 1998 from the Pontifical University of John Paul II; his doctoral advisor was Edward Staniek [pl].

[4] On 14 August 2004, Guzdek was appointed by John Paul II as auxiliary bishop of Kraków and titular bishop of Treba; he was consecrated on 15 September at the Divine Mercy Sanctuary by Franciszek Macharski, assisted by Józef Kowalczyk and Stanisław Dziwisz.