He was the first Polish composer living before the Second World War to apply the twelve-tone composition technique (dodecaphony).

[1][2] He must have come into contact with Edward Clark, the British conductor, BBC music producer and former student of Arnold Schoenberg, as his "Variations on a Waltz by Johann Strauss", Op.

[3] When German troops entered the town Koffler was captured with his wife and son and forcibly relocated to the ghetto in Wieliczka (Poland).

At the beginning of 1944 he and his family were probably killed by one of the German Einsatzgruppen near Krosno (in southern Poland) where he was hiding after the liquidation of the ghetto in Wieliczka.

Koffler's 1938 arrangement of J. S. Bach's Goldberg Variations for small orchestra was given its UK premiere on 11 June 2019, at Wigmore Hall, with London's Royal Academy of Music Soloists Ensemble and Toronto's Glenn Gould School, conducted by Trevor Pinnock.