[1] Mehoffer was born in Ropczyce, studied painting at the Academy of Fine Arts in Kraków under Władysław Łuszczkiewicz, and later at the Academy of Fine Arts in Vienna, as well as in Paris at the Académie Colarossi among others.

There Mehoffer began painting portraits, often of people of historical significance.

He later expanded his work to include different techniques, such as graphic art, stained glass, textiles, chalk drawings, etchings and book illustrations.

Mehoffer received international acclaim for his stained glass windows in the Gothic St Nicholas Collegiate Church in Fribourg, Switzerland produced in 1895–1936.

Mehoffer explored various media further throughout his career to include a range of applied arts in his projects.