He played in Major League Baseball (MLB) for the Toronto Blue Jays, Texas Rangers, and Tampa Bay Rays from 2010 through 2015.

He later played for the Under-18 Florida Bombers alongside future major leaguers Mat Latos, Gaby Sánchez, Yonder Alonso, and Jon Jay.

[citation needed] While in college, Arencibia played with Chase Headley, Luke Hochevar, and Julio Borbon.

Arencibia struggled during the early part of the season but hit well during the stretch and into the playoffs, helping the Doubledays win the NY-Penn League championship.

By the FSL all-star break, he led the league or was near the top in many offensive categories, finishing the first half of the season batting .315 with 13 homers, 22 doubles and 62 RBI.

After the game, the Blue Jays promoted him to their Double-A team, the New Hampshire Fisher Cats of the Eastern League.

For the 2009 season, Arencibia was promoted to the Las Vegas 51s, the Blue Jays' Triple-A affiliate in the Pacific Coast League.

[4] Arencibia was called up to MLB on August 4, 2010, to replace the injured John Buck, who had been placed on the 15-day disabled list for a right thumb laceration.

At the time of his promotion, Arencibia was batting .303 with a PCL leading 31 home runs and 79 RBI[5] He started in his first MLB game for the Toronto Blue Jays on August 7, 2010, against the Tampa Bay Rays.

In addition, he became the first person in the modern era with four hits and two home runs in an MLB debut, a feat set 121 years before by Columbus Solons catcher Charlie Reilly.

[8] On August 18, 2010, Arencibia was optioned back to Triple-A Las Vegas to make room for the return of John Buck from the disabled list.

On May 6, 2013, Arencibia hit a two-run home run to give the Blue Jays an 8–7 lead against the Tampa Bay Rays, in a game where they had been down 7–0 after the third inning.

[22] It was to be a rare 2013 highlight for Arencibia, who was a consistent target of criticism from both the fans and the press for his poor statistical performance that year.

[35] On August 13, 2014, Arencibia took the mound for the first time in his career and pitched the 9th inning for the Rangers who were losing to the Tampa Bay Rays 10–1.

[38] On January 8, 2015, the Baltimore Orioles announced that they had signed Arencibia to a minor league contract with an invitation to spring training.

[40] On April 16, he signed a minor league contract with the Tampa Bay Rays, and was assigned to the Triple-A Durham Bulls.

[28] The Philadelphia Phillies announced on December 14, 2015, that Arencibia had been signed to a minor league contract with an invitation to spring training.

[47] On May 20, 2016, Arencibia signed a minor league contract to return to the Tampa Bay Rays organization, and was assigned to the Triple–A Durham Bulls.

[52] Arencibia was named a studio pre and postgame analyst for Marlins broadcasts on Fox Sports Florida on February 12, 2019.

His maternal grandparents were Basque and Canarian descent, and immigrated to the United States from Cuba when his mother was two years old.

[58] In March 2021, he apologized publicly for threatening a comedian who had "trolled" Lahren about Donald Trump losing the 2020 United States presidential election.