[6][5] The hedge fund has made activist investments in Apple Inc., Tiffany's, Whole Foods, ConAgra, PetSmart, Walgreens Boots Alliance, Apache, URS, Safeway, Ashland, Marathon Petroleum, McGraw Hill, CNET, and Kerr-McGee.

The hedge fund pushed Petsmart towards a sale, and the company was bought in December for $8.7 billion by a group of buyers led by BC Partners.

[11] In 2017, JANA Partners revealed an 8.8% stake in Whole Foods[12] and stated intentions to make changes to the board of directors as well as improve the company's use of technology.

[22] In June 2018, Apple released a new iOS feature called "Screen Time" aimed at increasing awareness of potential tech addiction.

[26][27] The fund's co-portfolio managers are Daniel Hanson and Charles Penner,[28] and the new advisory board includes musician Sting, his wife Trudie Styler, Sister Patricia A. Daly and Robert Eccles.