The base sits alongside the United States Fleet Activities Yokosuka.

On 26 April 1952, the Coastal Safety Force was established from the Japan Coast Guard, and the Coastal Safety Force Yokosuka Regional Supervision Department was established at the site of the former Suirai Naval Academy (currently the 2nd Technical School) in Tauraminatocho.

On September 1, Yokosuka Education Corps was newly established in the Takeyama area.

On March 1, the Explosive Ordnance Disposal Unit was newly added to the Yokosuka Defense Force.

December 27, 1977, the Maritime Self-Defense Force Diving Medical Experiment Team is newly established in the Kurihama area.

On 31 March 1988, the Self-Defense Forces Yokosuka Hospital was relocated to its current location (Taura District).

On 26 March 2012, Yokosuka Guard Kannonzaki Guard Station was abolished and on September 1, Self-Defense Forces Yokosuka Hospital Education Department moved from Kurihama area to Taura area.