The Asagiri class is equipped for combat and interception missions, and is primarily armed with anti-ship weapons.

[citation needed] On 26 July 2013, she set sail off the coast of Somalia with the escort ship JS Ariake as the 16th dispatched anti-piracy action surface corps.

At the same time, it is the first Maritime Self-Defense Force ship to call at Cam Ranh Bay, a strategic point in central and southern Vietnam.

[3][4] At around 10:50 pm on 26 August 2017, the SH-60J patrol helicopter on board the ship lost communication during night training.

[5][6][7] On 3 December 2017, Setogiri departed from Ōminato for the Gulf of Aden off the coast of Somalia as the 29th dispatched anti-piracy action surface unit and engaged in missions until April 2018.