Antonoff has produced and co-written songs with other music acts such as Taylor Swift, Lorde, Lana Del Rey, St. Vincent, Pink, Kendrick Lamar and Sabrina Carpenter.

His other Album of the Year nominations include Lorde's Melodrama (2017), Swift's Evermore (2020) and The Tortured Poets Department (2024); Del Rey's Norman Fucking Rockwell!

Having won Producer of the Year three consecutive times from 2022 to 2024, Antonoff has been credited by critics with having influenced the popular music trends of the 2010s and 2020s decades.

(2023), and "Fortnight" (2024), Sabrina Carpenter's "Please Please Please" (2024), and Kendrick Lamar's "Squabble Up" (2024) —have topped the United States Billboard Hot 100 chart.

He has curated film soundtracks as well, including One Chance (2013), Fifty Shades Darker (2017), Love, Simon (2018), and Minions: The Rise of Gru (2022); singles from the first two soundtracks, "Sweeter Than Fiction" by Swift and "I Don't Wanna Live Forever" by Swift and Zayn Malik, have garnered nominations for the Grammy Award for Best Song Written for Visual Media.

[5] His younger sister, Sarah, died of brain cancer at the age of 13 when Jack was a senior in high school.

Antonoff explained in 2014: "Half the time no one would show up or the equipment would be too fucked up to play... but that's when I fell in love with touring."

[10] The group was popular on the jamband festival circuit and Antonoff has said he has applied that grassroots mentality to his future projects.

[16] In 2008, Nate Ruess (formerly the frontman of the Format) asked Antonoff to join him and Andrew Dost (formerly of Anathallo) in a new band, which became Fun.

The songs for the debut Bleachers album were mostly written on Antonoff's laptop computer in hotel rooms during a Fun.

"[23] Antonoff revealed the intent behind the debut single in a Rolling Stone interview: I wanted to bridge the gap between Disclosure and Arcade Fire—something both streamlined and organic...

[21] Antonoff worked with producers John Hill and Vince Clarke on the Bleachers studio album, as he sought to create "massive, beautiful pop songs that sound __ cool."

[28] In 2013, Antonoff wrote and produced the song "Sweeter than Fiction" with American singer-songwriter Taylor Swift, for the film One Chance.

[30] On the deluxe version of the album, Swift explains in a voice memo that the song "I Wish You Would" originated from a guitar track that Antonoff had recorded on his smartphone.

[34][35] Aside from "Look What You Made Me Do", Swift and Antonoff also wrote and produced five other songs together on Reputation—"Getaway Car", "Dress", "This Is Why We Can't Have Nice Things", "Call It What You Want", and "New Year's Day".

[50] The album broke numerous consumption records, leading publications to opine that it "cemented Swift as the biggest pop star this century by many metrics"[51] and became the longest-leading chart topper of her career.

[53] Rolling Stone praised Antonoff's production specifically, noting his use of "empty space to spectacular effect, [as] the arrangements veer from stark clarity to delirium.

On July 22, 2019, Red Hearse made their television debut on The Tonight Show Starring Jimmy Fallon, performing "Half Love".

[62] Antonoff co-produced Lana Del Rey's sixth studio album Norman Fucking Rockwell!, which was released on August 30, 2019.

The album received critical praise with NME's Rhian Daly noting that the "bohemian folk" sound of the record was a departure from Antonoff's "brand of crystalline euphoria.

[67][68] In 2015, Antonoff started his own music festival called Shadow of the City,[69] which raises funding for The Ally Coalition.

[72] The first festival, held on September 19, 2015 at The Stone Pony in Asbury Park, NJ, featured Charli XCX, Vic Mensa, the Front Bottoms, MisterWives, Cults, How to Dress Well and Robert Delong, with Bleachers headlining.

[73] Subsequent festivals included the artists Carly Rae Jepsen, The 1975, Brian Fallon, Khalid, Titus Andronicus, Nicole Atkins, Hayley Kiyoko, Julien Baker, Japanese Breakfast, and others.

[75] The quickly written song was released on April 23, 2013 and by the end of June, "Brave" had sold 160,000 digital copies and peaked at number 61 on the Billboard Hot 100 chart.

It hosts an annual benefits concert, called "The Talent Show," which has raised more than $2 million to support LGBT issues.

It was released in six 15-minute episodes and included cameos from Lena Dunham, Rosie Perez, Olivia Wilde, Colin Quinn, and Jason Mantzoukas.

The same year, he contributed to St. Vincent's sixth studio album, Daddy's Home,[84] and Clairo's sophomore record, Sling.

[86][87] He also co-produced the 1975's fifth studio album, Being Funny in a Foreign Language, and the soundtrack for the animated film, Minions: The Rise of Gru.

[94] He co-wrote and produced five tracks on Sabrina Carpenter's sixth studio album Short n' Sweet, including her first number-one single "Please Please Please".

[99] Also in 2024, Antonoff wrote and produced tracks from Lamar's sixth studio album GNX, including the number-one single "Squabble Up".