He is the only son and namesake of former Senate President Juan Ponce Enrile of Cagayan and the former ambassador to the Holy See, Cristina Castañer of Manila.

He then earned a Bachelor of Arts in English degree from Christian Heritage College, El Cajon, California in 1993.

He has a Presidential master's degree in business administration from Pepperdine University, Malibu, California (1995).

He is the principal author of the Batas Kasambahay, Food for Filipinos First, Credit Access and Protection Reform and the Anti-Monopoly Bill.

He ran again in 2016 to get back his previous position as representative of the 1st District of Cagayan but lost to Ramon Nolasco.