He won the first[9] and eighth event of the International Open Series, and finished first in the rankings,[10] so he received a place on the 2010/2011 professional Main Tour.

[16] Lisowski also qualified for the Shanghai Masters with wins over David Grace, Mike Dunn and Marco Fu, before defeating amateur Rouzi Maimaiti in the wildcard round.

[16][18] The 2012/2013 season was a breakthrough year for Lisowski, as he qualified for five ranking tournaments, including the World Championship, and reached his second final as a professional.

[19] The first tournament he got to play in was the Australian Goldfields Open in Bendigo, by beating Dave Harold; he then lost 2–5 to Mark Davis in the first round.

He played his good friend Judd Trump, and made a 131 break in a 5–3 win,[22] then came back from 2–4 down to triumph 5–4 against Mark Davis, reaching his first ranking event quarter-final.

[24] Lisowski played in nine minor-ranking Players Tour Championship events during the season, and reached the final in the first one by seeing off Trump in the quarter-finals, and Mark Williams in the semis.

[19] The final against Stephen Maguire went to a deciding frame with Lisowski missing a yellow off the spot, when requiring two further pots to leave his opponent needing snookers.

[19] In the World Championship Qualifying, he had comfortable 10–4 wins over James Wattana and Fergal O'Brien to reach the Crucible for the first time, where he played Barry Hawkins.

[27] The experience and composure of Hawkins told as he took the match 10–3, with Lisowski citing the intimate nature of playing at the Crucible, which affected his concentration, as a factor in the one-sided scoreline.

[29] Lisowski began the 2013/2014 season by qualifying for the 2013 Wuxi Classic, where he whitewashed Tian Pengfei 5–0 in the first round, before being narrowly beaten 5–4 by Mark Williams in the second.

[30][31] At the European Tour event, the Antwerp Open, Lisowski won five matches to advance to the semi-finals, where he lost 4–2 to Mark Selby.

Lisowski won a trio of matches for the second time this season to reach the Shanghai Masters, where Ding Junhui eliminated him 5–1 in the opening round.

[35] After Lisowski beat Chris Melling 6–1 at the UK Championship, he said that he was hoping to rediscover his confidence after having a quiet start to the year.

[42] Lisowski knocked out Zak Surety and Graeme Dott at the UK Championship, but bemoaned the fact that he could not translate that form to the main arena in the third round as he lost 6–4 to David Grace.

[45] Lisowski progressed through to the last 16 of the Northern Ireland Open by defeating David Lilley 4–3, John Astley 4–1 and Joe Perry 4–3, but was thrashed 4–0 by Barry Hawkins.

He advanced to the quarter-finals in the English Open in October after his wins over Rory McLeod, Li Yuan, Mark Williams and Judd Trump, before losing 5–2 to the eventual champion Ronnie O'Sullivan.

[48] Later in the season Lisowski advanced to another ranking event quarter-final in the China Open in April, this time narrowly defeated 6–5 by Kyren Wilson.

[70] At the end of the season, in the 2022 World Snooker Championship Lisowski wished to wear a badge with the flag of Ukraine on his waistcoat during his match against Matthew Stevens, in opposition to the Russian invasion of Ukraine, but the World Snooker Tour refused, stating that "our policy is to not allow our sport to be used as a political platform".

[75] On 29 April Lisowski joined the team in the BBC studio for analysis of the semi-final match between Judd Trump and Mark Williams.

[84] At the end of the calendar year, Lisowski participated in the second of two exhibition events held in Macau, China, reaching the final, but despite making a maximum break during the match, he lost 6–9 to Mark Williams.

[85] In January, he won his first match against reigining world champion Luca Brecel 6–2[86] to make it to the quarter-final stage of the 2024 Masters, but there he lost 3–6 to Shaun Murphy.

[87] At the end of the season, for the first time since 2018, Lisowski had to qualify for the 2024 World Championship as he dropped out of the top 16 due to his poor performance throughout the snooker year.

He did reach the main stage at the Crucible, but after a 10–9 victory over Ding Junhui,[88] he exited the tournament in the second round, as he lost 11–13 to Stuart Bingham.