As Manager John E. Manning (December 20, 1853 – August 15, 1929) was an American Major League Baseball player.

Born in Braintree, Massachusetts, United States, he broke into the National Association in 1873 at the age of 19.

His career covered 12 seasons, eight teams, and three leagues.

On October 9, 1884, when his Philadelphia Quakers ballclub were visiting the Chicago White Stockings in Lakeshore Park, he hit three home runs in the same game, becoming the third player to do so.

The first occasions were done by Ned Williamson and Cap Anson.