He is known for his recurring role as Mark Del Figgalo in the Nickelodeon/Family television series Zoey 101 where he appeared in 28 episodes.

Salvatore appeared on How I Met Your Mother and had a small role in the Owen Wilson feature Drillbit Taylor.

He appeared in an episode of Mind of Mencia and The Secret Life of the American Teenager, and had a recurring role on 10 Things I Hate About You.

On January 12, 2023, Jamie Lynn Spears announced that production had begun on a sequel film entitled, Zoey 102, set to premiere in 2023 on Paramount+, with original series cast members Spears, Salvatore Jr., Sean Flynn, Christopher Massey, Erin Sanders, and Matthew Underwood reprising their roles from Zoey 101.

[12][13] In March 2024, Salvatore Jr. claimed that Dan Schneider and that he once brought a shotgun to set to threaten actors and work crew.