It is operated by the Jackson Transit System and serves Amtrak's City of New Orleans and later proposed Crescent Texas section rail line, Greyhound Lines intercity buses, and is Jackson's main city bus station.

The city became a more prominent rail hub after the American Civil War as a stop for what eventually became the Illinois Central Railroad.

The modern Georgian Revival station was built in 1927 by Illinois Central when the rail lines were rebuilt through downtown.

The city undertook a $20 million renovation funded by the Intermodal Surface Transportation Efficiency Act and the Jackson Redevelopment Authority; Dale and Associates were chosen as architects.

The city converted the building into the Jackson Transit System's primary bus station and added facilities for Greyhound Lines.