Jackson Uptown Commercial Historic District is a national historic district located at Jackson, Cape Girardeau County, Missouri.

It developed between about 1880 and 1953, and includes representative examples of Classical Revival style architecture.

Notable buildings include the Cape Girardeau County Savings Bank (c. 1885, 1952), Kertsners's Drug Store (c. 1900), Cape Girardeau County Courthouse (c. 1906–1908) designed by P.H.

[2] It was listed on the National Register of Historic Places in 2005.

This article about a property in Cape Girardeau County, Missouri on the National Register of Historic Places is a stub.