[11] In 1931, Blaustein established the American Trading And Production Corporation (ATAPCO)[12] which was formed to consolidate and diversify the family's business activities and investments.

[1] Blaustein traveled on a post-war mission to Germany in 1946 at the invitation of Commanding General of the United States Forces in the European Theater Joseph T. McNarney, he made a survey of Displaced Persons Camps.

Blaustein led the American Jewish Committee's (AJC) Delegation to the Paris Peace Conference where he advocated for the strengthening of human rights clauses in the treaties and the inclusion of guarantees to aid victims of persecution through reparations.

[17] In 1960, Blaustein negotiated with the manufacturers of Krupp armaments to award compensatory damages for each slave laborer employed in their factories during the war.

[18] While he was at the San Francisco Conference, Blaustein helped to convince Soviet Foreign Minister Vyacheslav Molotov to accept the human rights articles of the UN Charter.

Blaustein was an astute and trusted dealmaker and undertook diplomatic missions to Germany, Israel, North Africa, Morocco, Turkey, Greece, Poland, and South America on behalf of the United States.

[20] During this period, Blaustein became close friends with Secretary-General of the United Nations Dag Hammarskjöld, and he accompanied him on a number of diplomatic missions.

[28] During his time as leader of the AJC, the organization took the position that fighting prejudice towards Jews in the United States could best be achieved by working to advance equality of all Americans.

[30] The AJC's social science research was cited in the 1954 Brown v. Board of Education decision of the U.S. Supreme Court that outlawed school segregation.

[36] Blaustein served as an informal and trusted advisor to a number of US presidents, including Franklin D. Roosevelt, Harry Truman, John F. Kennedy, and Lyndon B.

[39] President Truman became a close personal friend of Blaustein,[40] often asking him to report directly to him after his foreign trips and advise him on international and domestic issues.

[44] President Kennedy appointed Blaustein to the board of governors of United Service Organizations and to the Federal Advisory Committee on International Business, met with him on multiple occasions to seek his advice on foreign and domestic policy matters, Middle East refugee crises, and invited him to multiple state dinners.

Johnson also appointed Blaustein to serve as a member of the President's Commission on Marine Science, Engineering and Resources, and as a trustee of the Eleanor Roosevelt Memorial Foundation in 1964.

[3] Blaustein enjoyed listening to classical music and was a noted collector of a variety of paintings by Vincent van Gogh, Paul Gauguin, André Derain, Camille Pissarro, and Maurice Utrillo.

[55] Blaustein served as a board member of a number of organizations including the Dag Hammarskjöld Foundation, Hebrew University of Jerusalem, Weizmann Institute of Science, Atlantic Council, the Signet Banking Corporation, and the Associated Jewish Charities and Welfare Fund.

[19] The foundation serves as a benefactor of the Jacob Blaustein Institutes for Desert Research and Center for Scientific Cooperation at the Ben-Gurion University of the Negev in Israel.

[61] In a 2015 speech commemorating the 70th anniversary of the UN Charter, Speaker of the U.S. House of Representatives Nancy Pelosi delivered remarks where she recalled meeting then-Senator John F. Kennedy at a dinner honoring Blaustein in the 1950s.