Tremblay subsequently starred as a child with Treacher Collins syndrome in the drama Wonder (2017) and a naive sixth grader in the comedy Good Boys (2019).

He has since taken on voice roles as Damian Wayne / Robin in Harley Quinn (2019), the title characters in Luca (2021) and Orion and the Dark (2024), and Flounder in The Little Mermaid (2023).

[9] That same year, he starred in the horror film Before I Wake, with Kate Bosworth and Thomas Jane,[10] and played a supporting role in the psychological thriller Shut In, alongside Naomi Watts, and co-starring Oliver Platt,[11] and directed by Farren Blackburn.

[13] In 2017, Tremblay played Peter Carpenter in director Colin Trevorrow's drama film The Book of Henry, co-starring with Naomi Watts and Maddie Ziegler.

Good Boys earned $21 million during its opening weekend, becoming the first R-rated comedy since The Boss, which was released in April 2016, to finish first at the box office.

Tremblay brought his fellow actors to tears with his cameo performance in Doctor Sleep, the 2019 sequel to The Shining,[17] as a kidnapped boy who is tortured to death in a scene which director Mike Flanagan initially feared would be too traumatic to include in the final cut.