The Jacob VanderSys House is a historic residence in Mobile, Alabama, United States.

It was built in 1927 in the Spanish Colonial Revival and Mission Revival styles.

[2] The building was placed on the National Register of Historic Places on July 12, 1991.

It is a part of the Spanish Revival Residences in Mobile Multiple Property Submission.

This article about a property in Alabama on the National Register of Historic Places is a stub.