Jacobs Creek is an unincorporated community in Westmoreland County, Pennsylvania, United States.

[1] The community is located at the mouth of Jacobs Creek on the Youghiogheny River, 1.5 miles (2.4 km) south of Smithton.

Jacobs Creek has a post office with ZIP code 15448, which opened on December 14, 1865.

[2][3] The community was named after Jacobs Creek, a tributary of the Youghiogheny River, which in turn was named after Captain Jacobs, a local Lenape chief who lived along the creek in the mid 1700s,[4] and was killed in 1756 by Colonel John Armstrong's Expedition which wiped out the Native American village of Kittanning.

[8][9] In December 1907, an explosion at the Darr Mine killed 239 men and boys from Jacobs Creek and the nearby settlement of Van Meter.