Jacopo Sadoleto (July 12, 1477 – October 18, 1547) was an Italian Catholic cardinal and counterreformer noted for his correspondence with and opposition to John Calvin.

He was born at Modena in 1477, the son of a noted jurist, he acquired reputation as a Neo-Latin poet, his best-known piece being one on the group of Laocoön.

In Rome, he obtained the patronage of Cardinal Oliviero Carafa and adopted the ecclesiastical career.

[2] A faithful servant of the papacy in many negotiations under successive popes, especially as a peacemaker, his major aim was to win back the Protestants by peaceful persuasion and by putting Catholic doctrine in a conciliatory form.

Pope Paul III recalled him once more and made cardinal in 1536, given the titular church of San Callisto.