Jacqueline Humphries (born November 17, 1960, in New Orleans) is a renowned American abstract painter married to Tony Oursler.

[1] She is known for her large-scale paintings that reference the history of abstraction, combining traditional painterly techniques with contemporary technologies.

She has used metallic silver pigment to suggest the glow of a cinema screen, and has incorporated emoticons, emoji, kaomoji, and CAPTCHA tests into recent works that draw on digital communication.

[18] In 2020, she co-curated an exhibition with fellow board member Wade Guyton to celebrate The Kitchen's fifty-year anniversary.

[19] Previously, Humphries served as a board member at Participant Inc., an educational corporation and not-for-profit alternative art space founded in 2001.