After the National Constituent Assembly formed on 9 July 1789 Creuzé-Latouche became judge of the High Court of Orleans, while continuing to play an active role in the Châtellerault Jacobin Society.

On 5 March 1792 he voted to requisition objects of worship made of precious metals so they could be used to make coins and ingots.

Due to his positions on free trade and his collaboration with several periodicals associated with Jean Marie Roland and Jacques Pierre Brissot he was clearly one of the Girondins.

At the trial of King Louis XVI of France he voted against the appeal to the people, for detention followed by banishment and then for suspension.

[1] Due to Creuzé-Latouche's relative lack of political activity he was not included in the arrests that followed the fall of the Gironde in the insurrection of 31 May – 2 June 1793.

[1] On 31 January 1795 Creuzé-Latouche spoke in the National Convention calling for the addition of a chair in political economy in the newly established École Normale.

[4] On 21 Vendémiaire, year IV, Creuzé-Latouche was appointed to the Council of Ancients, where he played an important role in the fight against the clergy.