The basic architecture of the Guibourd House is very similar to other Creole-French structures around the town and throughout the French inhabited regions of the Illinois Country/territory, eastern Canada and the Louisiana territory.

The structure's design has been changed only slightly over the years to accommodate the needs of the various residents, but overall retains much of the original character and style of the early 19th century French Creole architecture.

(Contrary to the myth that kitchens were separate from the house due to the dangers of fire in the food preparation areas, extensive research has been done on the subject with no substantial facts to back it up.

The interior walls were often plastered and white-washed, and in more luxurious homes were sometimes frescoed or painted in panels, as in the Laclede-Chouteau house; but the ceilings were left open to show the carefully shaped beams (soUveaux), with their beaded moulding, and the attic flooring.

Shrines and tall wooden crosses on inscribed stone pedestals added to the European appearance of the early settlements.

The immigration which began about the time of the American Revolution, and reached its full tide after the War of 1812, destroyed most of the Creole architectural traditions.

Charles Dickens, visiting St. Louis in 1842, found that "In the old French portions of the town the thoroughfares are narrow and crooked, and some of the houses are quaint and picturesque, being built of wood, with tumble-down galleries ... and an abundance of crazy old tenements with blinking casements, such as may be seen in Flanders.

He and Moros made their way back to France whereupon seeing the chaos and destruction there caused by the Reign of Terror (1793–94, just after the French Revolution of 14 July 1789) had decided to leave their homeland.

While the house was being built, Jacques opened a mercantile and sold goods to villagers from his residence just across the street from La Maison de Guibourd.

Jacques' son, Eugene, married Marie Therese St. Gemme Beauvais and had 12 children most of whom were born in Old Mines, Washington County, MO.

In 1859 according to the HABS survey, Jules and Omer sold their part of the lot to Eugene and it subsequently became the property of his son, Felix.

... he had gone to the fatal island of San Domingo [Saint Domingue or Haiti], from which he, like so many other Frenchmen, emerged a victim of the cruel barbarism of the blacks, at that time slaves in revolt.