Soon after the release of their hit debut album, El Equilibrio de los Jaguares, Hernández took a break after suffering papiloma virus cancer.
Aguilera was replaced by César López Garcia, most famously known as "El Vampiro", who had previously been invited to play in Caifanes' beginnings in the late 1980s.
In 2001 Jaguares released "Cuando La Sangre Galopa" with Chucho Merchán as bassist and Leo Muñoz as a percussionist.
It is a compilation album of various artists covering songs of John Lennon to benefit Amnesty International's campaign to alleviate the crisis in Darfur.
On January 14, 2019, it was announced that Jaguares will reunite for a single concert as part of Machaca Fest 2019 in Monterrey, Nuevo Leon.