Three of the first four games played between the two teams were close affairs; the exception, a 27–0 Jaguars blowout win was the first shutouts suffered by the Texans in their franchise history.

The Texans won the game 21–19 as Kris Brown kicked a game-winning field goal with 54 seconds left to help Houston earn its first away victory in franchise history.

While Gabbert flamed out after three seasons in Jacksonville and was eventually traded, Watt became a three-time NFL Defensive Player of the Year winner and, in the process, became a notable figure of the rivalry.

[11] Playing at home, they were nearly upset by the Jaguars, but quarterback Matt Schaub completed a touchdown pass to wide receiver Andre Johnson with two minutes left in overtime to secure a victory.

In 2022, Sports Illustrated writer Zach Dimmit wrote "It might be hard to find a more historically lopsided division rivalry in the league.

[17] However, during the teams' second matchup of the season, Jacksonville blew out the Texans 31–3,[18] snapping Houston's 9-game winning streak in the rivalry series.

In Week 12, the two teams battled in a close game with both quarterbacks throwing for over 300 yards, with the Jaguars ending up winning 24–21 from a missed game-tying field goal by Texans kicker Matt Ammendola.

In 2024, the rivalry intensified further when Texans linebacker Azeez Al-Shaair illegally hit quarterback Trevor Lawrence as he was sliding a yard short of a first down.