He is affiliated with the Christian Social Party (PSC) and the Madera de Guerrero Civic Movement [es].

[5] Nebot entered politics in 1984, when he was appointed governor of Guayas province (the district encompassing Guayaquil) by then-president León Febres-Cordero.

[6] During his tenure as governor he sent police on a three-day operation to evict more than 700 families who were squatting on private land in Guayaquil.

[7] During an incident in Taura when President Febres-Cordero was kidnapped by some military officials led by Vargas Passo, Nebot played an important role in the negotiations for his freedom.

In 1990 Nebot ran for congress on the Christian Social Party slate and won a seat representing Guayas province.

On August 31 of that year, while a parliamentary session was being broadcast on TV, Nebot, visibly agitated, began shrieking at a fellow congressman, Víctor Granda of the Socialist Party.

[13] Nebot, supported by large agricultural businesses from the coast, spoke at home of more social services.

[14] Nebot was also harmed by an untimely remark from his party boss and political mentor, León Febres-Cordero, who said on TV that Bucaram "was the candidate of pimps, prostitutes, and marijuana users.

[20] After Bucaram's overthrow, Nebot, at the head of Social Christian Party slate, won a seat in an assembly that redrafted Ecuador's constitution.

In 2002, Nebot hired former New York City Police Commissioner William Bratton to help draft an anti-crime strategy.

Guayaquil's new anti-crime strategy included tough penalties for individuals caught begging or selling on the streets of the gentrified areas.

[25] Nebot built a shopping promenade Malecón 2000 along the west bank of the Guayas River, in the center of Guayaquil.