Jaime Manuel Penedo Cano (born 26 September 1981) is a Panamanian former professional footballer who played as a goalkeeper for various teams such as: Osasuna B, CSD Municipal, LA Galaxy, Deportivo Saprissa and Dinamo București, among others, but also for the Panama national team, being the goalkeeper of the first squad of Panama that ever played in a World Cup.

On 5 August 2013, the 2015 CONCACAF Gold Cup Bronze medal-winning goalkeeper signed with the LA Galaxy.

[5][6] He made his Galaxy debut on 7 August 2013 in a mid-season friendly against AC Milan in the inaugural International Champions Cup.

Penedo made his debut for Panama in June 2003 as a substitute for Francisco Portillo in a 1–0 win over Cuba.

He has, as of 11 July 2015, earned a total of 122 caps including an unofficial match against Mexico in 2007, scoring no goals.