[1] Carlisle made his debut in Round 20 of the 2010 AFL season, against Collingwood, a game which the young team lost by 98 points.

"[2] He had a break-out 2012, his consistency in the back-line did not go unnoticed, earning an AFL Rising Star nomination against Greater Western Sydney in Round 9.

Fearless around packs and a strong contested mark, his impressive season was cut short with a foot injury in Round 19.

[4] In October 2015, after much deliberation, Carlisle nominated St Kilda over Carlton as the club he wished to be traded to from Essendon.

He was suspended for two years which, with backdating, ended in November 2016; as a result, he served approximately fourteen months of his suspension and missed the entire 2016 AFL season.

[9] He had also received a two-match internal suspension at St Kilda after footage emerged of him using recreational drugs, but the club later waived it, determining that it was served concurrently with the season-long ban.

Carlisle would have played more games, but was suspended for two matches for striking Richmond's Jack Riewoldt and suffered a punctured lung in another incident after a mistake by club doctors.

Carlisle played 13 of a possible 19 games in a Covid-interrupted season, including the Saints' elimination final win against the Western Bulldogs.

[16] In November, he received a strike under the AFL illicit drugs policy, a two-match suspension for the start of the 2016 season (which was served concurrently with his season-long ban arising from the supplements scandal),[10] and forfeited $50,000 in marketing money.