He has released 20 albums as a bandleader and became an renown artist on the international jazz scene after recording and touring with Paul Motian, Tomasz Stanko, Lee Konitz, Joe Lovano, Midori Takada, Brian Blade, Charles Lloyd a.o.

Bro also works with Palle Mikkelborg, Charles Lloyd, Ambrose Akinmusire, Midori Takada, Joe Lovano, and Bro/Knak, a collaboration with the Danish producer Thomas Knak.

Bro has worked with Paul Bley, Chris Cheek, Andrew D'Angelo, Bill Frisell, George Garzone, Lee Konitz, Thomas Morgan, Paul Motian, Oscar Noriega, Kurt Rosenwinkel, Chris Speed, Ben Street, Mark Turner, David Virelles, and Kenny Wheeler.

Jakob Bro got rewarded by the Danish Arts Foundation in 2006 and 2012 for his recordings Pearl River and Bro/Knak.

In 2009 and 2013 he received The Jazz Special Prize for Danish Jazz Album of the Year (for the albums Balladeering and December Song) and in 2013 he received The Jazznyt Prize founded by Niels Overgaard[5] (for December Song).