After Family Matters ended, White starred in the short-lived UPN comedy series Grown Ups (1999–2000) and appeared in supporting roles in the film Dreamgirls (2006) and on television on Boston Legal, House, Castle, Psych and Bones.

The film features an ensemble cast including Sherman Hemsley, Jennifer Aniston, and Brian Robbins.

Several other child actors of the era including Chad Allen, Candace Cameron, Danica McKellar, Josh Saviano, and Breckin Meyer also appear.

[10] The series was a staple of ABC's TGIF lineup and became one of the longest-running sitcoms with a predominantly black cast in television history.

[12] By the time the series ended in 1998, White, who was then 21 years old, was disillusioned with the role, and had been shaken by the death of his close friend and co-star Michelle Thomas from an aggressive form of stomach cancer.

[6] White was the original English-language voice of the popular video game character Sonic the Hedgehog, having been cast in 1993 (pre-dating Martin Burke and Ryan Drummond).

He also co-produced and wrote some episodes for the show, in which he starred as "J", a college graduate struggling to establish his role in life as an adult.

The pilot episode featured another former child actor, Soleil Moon Frye, known for her role as Punky Brewster, as the girl whom he chose as a roommate.

[21] In the series, White stars as Simon, a 30-something black man marrying a young Jewish girl named Rochelle.

In September 2009, White guest starred on the USA Network series Psych, as an estranged college singing buddy of the character Gus.

The series, which premiered on Hulu, follows the exploits of former child star Reggie Cullen (White) turned image consultant and his three protégés as they hustle to navigate Hollywood.

[22] In March 2011, White guest starred on the TBS sitcom Are We There Yet?, which reunited him with fellow Family Matters cast member Telma Hopkins.

Later that same year, White appeared as the star in Cee-Lo Green's music video for his song "Cry Baby".

[29] In 2017, it was announced that CBS picked up his single camera comedy series Me, Myself & I with Bobby Moynihan, that premiered in September 2017.

[35][36] On May 4, 2024, White married Nicoletta Ruhl, a sports technology business executive, in a ceremony in Los Angeles.

[37][38] White is a big fan of basketball and frequently played pickup games with George Clooney, who was taping ER in the studio next door.

[39] In 2021, White announced the launch of his line of cannabis products featuring the Purple Urkle strain, set for debut on April 20 at California dispensaries.