He was the founder of Molla Nasraddin, a satirical magazine that would greatly influence the genre in the Middle East and Central Asia.

[6] In 1887, he graduated from the Gori Pedagogical Seminary and for the next ten years was involved in teaching at rural schools in Bashnorashen (Sharur), Ulukhanli, Nehram and other towns and villages of the Erivan Governorate.

[9] He condemned many of his contemporaries for what he considered a corruption of the Azerbaijani language by replacing its genuine vocabulary with newly introduced Russian, Persian and Ottoman Turkish loanwords, often alien and confusing to many readers.

In March of 1903, he met one of a close friend and colleague Omar Faig Nemanzade who also becomes a prominent journalist in his own right.

Frequent military conflicts and overall political instability in the Caucasus forced him to move to Tabriz, Persia, where he continued his career as a chief-editor and columnist for Molla Nasraddin.

In the early days of the Magazine, It was banned in Iran and Turkey and in a satirical article in response to banned in issue of Molla Nasraddin no.36 6 December 1906 "We decided to increase our readership a little by distributing calendars and booklets; but that goddamn devil; everyday he comes to us and insists, for example, that we write that in Tabriz the successor to the throne assembles his ‘humble’ robbers and sends them to ransack Iran’s villages and cities and distributes part of the booty between them, keeping the rest for himself.

[11][better source needed] In 1905, Mammadguluzadeh and his companions purchased a printing-house in Tiflis, and in 1906 he became the editor of the new Molla Nasraddin illustrated satirical magazine.

The magazine accurately portrayed the social and economic realities of the early-20th-century society and backward norms and practices common in the Caucasus.