[2][3] Calhoun would make his collegiate debut in week one in the 2019 season, where he hauled in his first career pass for two yards, as Duke was crushed by Alabama 42–3.
[4] In week two, Calhoun would go off having a career day, catching eight passes for 105 yards and two touchdowns, as he helped the Blue Devils beat North Carolina A&T 45–13.
[5][6] Calhoun would have another good performance in week three bringing in six passes for 49 yards and a touchdown, as he would help Duke beat Middle Tennessee State 41–18.
[13] In week five, Calhoun would again have another good performance, making three catches for 38 yards and a touchdown, as he helped the Blue Devils pick up their first win on the season, beating Syracuse 38–24.
[29][30] Just a week later, Calhoun would have another great performance hauling in six receptions for 65 yards and a touchdown, as he helped Duke beat Virginia in a convincing fashion 38–17.
[31][32] In week eleven, Calhoun would have another dominating performance, bringing in five receptions for 94 yards, as he would help the Blue Devils beat Virginia Tech soundly 24–7.
[35][36] In the team's season finale, Calhoun would have arguably the best game of his career, bringing in 11 receptions for 174 yards and a touchdown, as Duke would beat Wake Forest 34–31.