James Britton Cranfill (September 12, 1858 – December 28, 1942) was an American religious figure and prohibitionist who served as the Prohibition Party's vice presidential nominee in 1892.

He began to study medicine under his father in 1870 and received his medical certificate at age 21 in 1879.

[1] On July 1, 1892, he narrowly defeated Joshua Levering for the Prohibition Party's vice presidential nomination with 416 delegates to 332 delegates after a story circulated that Levering was a member of the coffee industry.

[2] Cranfill was nominated despite the fact that, at 33, he was below the minimum constitutional age of 35 to serve as vice president.

[3] General John Bidwell was given the presidential nomination and the ticket received 270,813 votes for 2.24% of the popular vote which is the best performance of any Prohibition presidential ticket.