James Boyle Uniacke (1799 – 26 March 1858) led the first responsible government in Canada as it is today or any colony of the British Empire.

The son of Richard John Uniacke, James was born to politics and entered the colony's legislative assembly in 1832 as a Conservative.

In 1838 he joined the Executive Council and became a Reformer during the struggle for responsible government culminating in the 1848 election, the first under responsible government, which resulted in a Liberal Party administration led by Uniacke with Howe becoming more prominent after 1851 as Uniacke's health declined.

Uniacke lived for years with Rosina in what is now known as the Black-Binney House, which is now a national historic site.

This article about a Liberal party Member of the Nova Scotia House of Assembly is a stub.