James F. Byrnes High School is a public high school located in Duncan, South Carolina.

A part of Spartanburg County School District 5, it is named after the former Governor of South Carolina and U.S. Secretary of State, James F. Byrnes.

The current principal is Erin Greenway.

The James F. Byrnes Freshman Academy is situated at the former location of D. R. Hill Middle School.

This South Carolina school-related article is a stub.