Jacobo Francisco Eduardo Fitz-James Stuart y Colón de Portugal, 3rd Duke of Berwick (28 December 1718 – 30 September 1785) was a Spanish nobleman.

On the death of his father, James Fitz-James Stuart, in 1738, he inherited his titles of Duke of Berwick and Duke of Liria and Xerica.

His mother was Spanish, and on her side he was a direct descendant of explorer Christopher Columbus.

His wife was a sister of Fernando de Silva, 12th Duke of Alba, prime minister of Spain.

Their only son to survive to adulthood was Carlos Bernardo Fitz-James Stuart y de Silva, (Liria, Valencia, 25 March 1752 – Madrid, 7 September 1787).