James McClurg (1746 – July 9, 1823) was an American physician and Founding Father who served as a delegate to the Philadelphia Convention which drafted the United States Constitution in 1787.

McClurg, who was a surgeon in the Continental Army during the Revolutionary War, is believed to have owned a series of slaves over the course of his lifetime.

He was a graduate of the College of William and Mary, where he later served as a professor, and received his medical degree from the University of Edinburgh in Scotland in 1770.

[4] McClurg achieved renown in Richmond for his efforts to stop various epidemics, including the yellow fever in 1798.

However, his contagious disease focus later brought criticism in connection with the botched toxicological work in the celebrated trial concerning the murder of Judge George Wythe, whom he initially thought suffered from cholera, not arsenic poisoning.

[7] The French minister, Anne-César, Chevalier de la Luzerne, thereafter convinced New Jersey's John Witherspoon, who was paradoxically a pro-Lee Francophile, that diplomatic troubles would likely ensue should Lee be elected, and Witherspoon abstained, tilting New Jersey's vote and the election to Livingston.

[12] His daughter Elizabeth Selden McClurg eventually married John Wickham, a celebrated Richmond attorney.